Joachim graduated from University of Copenhagen (Denmark) in 2017 with both Bsc. and Cand. Scient. degrees in Biology-Biotechnology with specialization in Applied Enzymology. My work has mainly revolved around specialized metabolites but has also included post-translational modifications, such as glycosylation of proteins.
At University of Newcastle (UoN), I’m working on specialized metabolites from cyanobacteria, aka. blue-green algae. One group of specialized metabolites are polyketides (PKs), which are being produced by an enzyme group called polyketide synthase (PKS). Deciphering the potential of cyanobacteria to produce PKs are of importance due to their antimicrobial and immunosuppressive properties. However, the potential of PK production in cyanobacteria have been understudied. Therefore, heterologous expression of genes encoding PKS are carried in different host organisms to study their product formation and the biosynthesis of different PKs. Another exciting aspect of my projects here at UoN is to study the physiological function of these PKs from cyanobacteria, because the main reason for the production of these metabolites has not been elucidated yet. This is done by applying a combination of transcriptomics and metabolomics on the native host.
By combining molecular biology with analytical chemistry, it is possible to decipher a biosynthetic pathway, using a heterologous host as expression organism. Having experience with both molecular biology and analytical chemistry from previously projects, I have the experience and knowledge to carry out such a research project, from the molecular biology part to the final analytical chemistry. On top of that comes the knowledge provided by the BGGM team, which is specialized in investigating specialized metabolites and the techniques needed.